In vivo Release of Histamine from Rabbit Blood by Reserpine

Abstract
Reserpine (5 mg/Kg) injected into rabbits caused a release of histamine from blood platelets in the same manner as it does platelet serotonin. Whole blood histamine and serotonin reached a minimum level at 20 hours, remained low until 48 hours and returned to normal in 5-7 days.