Hepatitis b surface antigen production as a growth cycle-related terminal event in plc/prf/5 hepatoma cells
- 1 January 1980
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 5 (3), 257-264
- https://doi.org/10.1002/jmv.1890050310
Abstract
The dynamics of hepatitis B surface antigen production by PLC/PRF/5 hepatoma cells were studied using a quantitative radioimmunoassay method. Maximum rates of antigen production were found in nutrient‐depleted, non‐dividing cultures and were temporally related to cytological changes preceding cell death. These results indicate that antigen production may be cell‐cycle related and represent a terminal event.Keywords
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