Decreased Cloning of Lymphocytes from Elderly Individuals
- 1 April 1984
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 19 (4), 293-296
- https://doi.org/10.1111/j.1365-3083.1984.tb00933.x
Abstract
Limiting-dilution cloning of human lymphocytes was used to study cloning and proliferation of lymphocytes in 10 young and 10 elderly individuals. The cloning efficiency for elderly individuals, 3.5%, was significantly lower than that for young individuals, 19.8%. Mixing experiments showed that this decrease was due to both a decrease in the frequency of the clone-forming cells and a decrease in the interacting ability of the lymphocytes. Lymphocytes from elderly individuals which did form clones proliferated at the same rate as did those from young individuals.This publication has 14 references indexed in Scilit:
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