Caesium fluoroxysulphate as a mild fluorinating agent for the fluorination of alkoxy-substituted benzene and naphthalene derivatives

Abstract

Room-temperature fluorination of alkoxy-substituted benzene derivatives with caesium fluoroxy-sulphate in the presence of boron trifluoride as catalyst resulted in the formation of ortho- and para-fluro-substituted products, the ratio being dependent on the size of the alkoxy-group, while reactions with 2-alkoxy-naphthalene derivatives resulted in the formation of 1, 1-difluoro-2-oxo-1, 2-dihydronaphthalene as well as 1-fluoro-substituted products.