Delivery of Loperamide Across the Blood-Brain Barrier with Polysorbate 80-Coated Polybutylcyanoacrylate Nanoparticles
- 1 January 1997
- journal article
- Published by Springer Science and Business Media LLC in Pharmaceutical Research
- Vol. 14 (3), 325-328
- https://doi.org/10.1023/a:1012098005098
Abstract
Purpose. The possibility of using polysorbate 80-coated nanoparticles for the delivery of the water insoluble opioid agonist loperamide across the blood-brain barrier was investigated. The analgesic...Keywords
This publication has 8 references indexed in Scilit:
- Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)Brain Research, 1995
- Colloidal carriers for intravenous drug targeting: Plasma protein adsorption patterns on surface‐modified latex particles evaluated by two‐dimensional polyacrylamide gel electrophoresisElectrophoresis, 1993
- The polyoxyethylene/polyoxypropylene block co‐polymer Poloxamer‐407 selectively redirects intravenously injected microspheres to sinusoidal endothelial cells of rabbit bone marrowFEBS Letters, 1992
- Differential properties of organ-specific serum opsonins for liver and spleen macrophagesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1989
- The distribution and elimination of methotrexate in mouse blood and brain after concurrent administration of polysorbate 80Cancer Chemotherapy and Pharmacology, 1985
- Loperamide: Evidence of interaction with μ and δ opioid receptorsLife Sciences, 1983
- Effects of polysorbate 80 on the absorption and distribution of oral methotrexate (MTX) in miceCancer Chemotherapy and Pharmacology, 1982
- Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine.1974