A note on the stability of actinomycin D
- 1 June 1964
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 16 (6), 429-432
- https://doi.org/10.1111/j.2042-7158.1964.tb07486.x
Abstract
Visible absorption spectra and an agar-diffusion microbiological assay with Staphylococcus aureus were used to examine the effects of temperature, time, and pH on the stability of actinomycin D in distilled water, Clark and Lubs buffer solutions, and plasma. The most stable storage pH range for actinomycin D in buffer solution is 5 to 7. Actinomycin D in distilled water and stored 5° C (refrigeration) preserved its stability for at least 150 days. Except in buffer at pH 5, the antibiotic is appreciably degraded by autoclaving.Keywords
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