A Convenient Synthesis of (−)‐Paroxetine
- 12 July 2004
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 2004 (15), 3336-3339
- https://doi.org/10.1002/ejoc.200400067
Abstract
A convenient synthesis of the antidepressant paroxetine starting from 1‐benzyl‐4‐piperidone (2) is reported. A stereoselective reduction resulted in cis‐piperidine‐3‐methanol [(+)‐6]. The reaction between cis‐piperidine‐3‐methanol mesylate (7) and sesamol led to benzyl‐protected trans‐paroxetine (9) through an inversion reaction of the stereogenic center at position 3. The latter compound was deprotected by hydrogenolysis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)This publication has 12 references indexed in Scilit:
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