Liver Carcinogenesis by Diethylnitrosamine in the Rat
- 1 April 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 152 (3718), 83-85
- https://doi.org/10.1126/science.152.3718.83
Abstract
Diethylnitrosamine was continuously administered to rats at a dose rate of low toxicity. Ninety-two percent of the animals died with multicentrical hepatocellular carcinomata within a narrow and highly reproducible time interval. Discontinuing the carcinogen during the experiment resulted in a prolonged median time until death, a reduced tumor yield, and a lessened slope of the dose-response curve. Partial hepatectomy after discontinuation of the drug did not change either tumor yield or time of death. The obtained dose-response relationships support the concept that carcinogenic effects of single doses are irreversible and cumulative. Daily, low-dose, total-body x-irradiation had no significant effect on the response of rat liver to the carcinogen.This publication has 7 references indexed in Scilit:
- Dose-Response Relationships for Carcinogens: A ReviewEnvironmental Health Perspectives, 1987
- Cellular injury and carcinogenesis. Alkylation of ribonucleic acid of rat liver by diethylnitrosamine and n-butylmethylnitrosamine in vivoBiochemical Journal, 1964
- Methylation of Ribonucleic Acids of Liver and Other Organs in Different Species Treated With C14- and H3-Dimethylnitrosamines In Vivo23JNCI Journal of the National Cancer Institute, 1964
- Krebserzeugung durch Applikation von Diäthylnitrosamin und Röntgenstrahlen an RattenThe Science of Nature, 1963
- Quantitative Analyse der experimentellen KrebserzeugungThe Science of Nature, 1962
- Carcinogenesis by Ultraviolet LightPublished by Walter de Gruyter GmbH ,1959
- THE EFFECT OF LIVER REGENERATION ON TUMOR FORMATION IN RATS FED 4-DIMETHYLAMINOAZOBENZENEThe Journal of Experimental Medicine, 1951