Competitive Induction and Enhancement of Indole and a Diketopiperazine in Marine Bacteria
- 13 May 2004
- journal article
- research article
- Published by Springer Nature in Marine Biotechnology
- Vol. 6 (3), 215-220
- https://doi.org/10.1007/s10126-003-0010-z
Abstract
Thirteen bacterial strains isolated from a sample of Ulva californica were cultured, extracted, and assayed for antibiotic activity. The target strains were 2 gram-positive isolates from the same algal sample. When cultured in monoculture, 2 of the 13 isolates produced extracts with antimicrobial activity. More significantly, one Bacillus isolate (UA-094) produced indole and cyclo(Phe-Pro) at active levels upon challenge with a different Bacillus target strain. These mildly antibiotic compounds were barely detectable in extracts without challenge. This technique of competitive induction and enhancement could be a valuable tool in the search for new antibiotics.Keywords
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