In previous articles,1a method was described for the total removal of the liver from the dog, and a brief summary was made of the data obtained from a series of studies on the completely hepatectomized animal. The present report deals more in detail with one phase of our experiments; namely, the effect of hepatectomy on the sugar concentration of the blood. Method for Total Removal of the Liver of the Dog. —Since the method of removal of the liver has been fully described,1only a brief description will be given. The liver is removed in two stages. All operations are performed under ether anesthesia with aseptic surgical technic. The first operation consists of a reverse Eck fistula, that is, lateral anastomosis of the portal vein and the vena cava and ligation of the latter on the cephalic side of the stoma. At first a considerable portion of the blood