Effect of Vitamin B6 And Magnesium on Renal Deposition of Calcium Oxalate Induced by Ethylene Glycol Administration.

Abstract

Oral administration of ethylene glycol to rats and the resultant renal deposition of calcium oxalate were studied in terms of dietary levels of vitamin B6 and magnesium. Under the conditions of these experiments partial protection against oxalate deposition was achieved with excessive dietary vitamin B6 while complete protection resulted when large amounts of MgO were fed. The in vivo oxidation of ethylene glycol to CO2 was found to be related to amount of vitamin B6 administered. Dietary magnesium levels, however, did not affect oxidation of ethylene glycol and it is suggested that dietary magnesium protects against renal deposition of calcium oxalate by altering the solvent characteristics of urine.