Stimulation of ascorbic acid synthesis and excretion by carcinogenic and other foreign compounds
- 1 October 1961
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 81 (1), 163-168
- https://doi.org/10.1042/bj0810163
Abstract
Some foreign compounds increase synthesis and excretion of ascorbic acid in rats. A new method for the preparation of L-galactono-gamma-lactone by high-pressure catalytic reduction of D-galacturonic acid is described. The rate of conversion of L-galactono-gamma-lactone into ascorbic acid was the same in microsomes from normal rats and rats treated with 1,2-5,6-dibenzanthracene, which caused increased ascorbic acid excretion in the whole animal.Keywords
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