Bone modeling during growth: Dynamic strain equilibrium in the chick tibiotarsus

Abstract

Bone loading was quantified, usingin vivo strain recordings, in the tibiotarsus of growing chicks at 4,8, 12, and 17 weeks of age. The animals were exercised on a treadmil at 35% of their maximum running speed for 15 minutes/day.In vivo bone strains were recorded at six sites on the tibiotarsus. Percentages of the bone's length and a percentage of top running speed were used to define functionally equivalent sites on the bone, and a consistent exercise level over the period of growth was studied. The pattern of bone strain defined in terms of strain magnitude, sign, and orientation remained unchanged from 4–17 weeks of age, a period when bone mass and length increased 10-fold and threefold, respectively. Our findings support the hypothesis that bones model (and remodel) during growth to achieve and maintain a similar distribution of dynamic strains at functionally equivalent sites. Because strain magnitude and sign (tensile versus compressive) differed among recording sites, these data also suggest that cellular responses to strain-mediated stimuli differ from site to site within a bone.