Abstract
I discuss the effect of flavor mixing on proton-decay Hamiltonian in SU(5) grand unified theories with arbitrary number of fermion families and show that in the simplest model with only one {5} Higgs multiplet, all fermion interactions (with Higgs as well as gauge bosons) are describable in terms of a single mixing matrix. For the more complicated case of several {5} multiplets, the above feature persists for gauge-boson interactions though not for Higgs bosons.