THE EFFECTS OF MAGNESIUM UPON DENERVATED MAMMALIAN MUSCLE

Abstract

In-traven. MgSO4 eauses a depression of twitch height in denervated skeletal muscle of dogs. This is probably due to an increase of the threshold of the denervated muscle to electrical stimutilation. Mg temporarily reduces or may abolish the isensitivity of the denervated muscle to acetyl-choline, except after eserinization of the animal. Because of the direct action of Mg upon the muscle there are certain differences between the action of this substance and that of curare.