The Pharmacokinetics and the effect on blood 5-HT of paroxetine in man
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Nordisk Psykiatrisk Tidsskrift
- Vol. 33 (6), 450-454
- https://doi.org/10.3109/08039487909103168
Abstract
The pharmacokinetics of a new 5-HT uptake inhibitor, paroxetine, as well as its reduction of 5-HT in blood have been investigated in man. The pharmacokinetic studies revealed a good fit to a one compartment open model with elimination half life around 16 hours and an almost complete metabolism. Studies in patients showed a rather small interpatient variation in steady state plasma concentrations. Maximal reduction of 5-HT in blood was seen after treatment with paroxetine 25 mg orally once a day for around 10 days in volunteers as well as in patients.Keywords
This publication has 4 references indexed in Scilit:
- Paroxetine: Pharmacokinetics, Tolerance and Depletion of Blood 5‐HT in ManActa Pharmacologica et Toxicologica, 1979
- Potent depletion of 5HT from monkey whole bloob by a new 5HT uptake inhibitor, paroxetine (FG 7051)European Journal of Pharmacology, 1978
- Effects of 5HT uptake inhibitors on the pressor response to 5HT in the pithed rat. The significance of the 5HT blocking propertyEuropean Journal of Pharmacology, 1977
- EVIDENCE THAT 5‐METHOXY‐N, N‐DIMETHYL TRYPTAMINE IS A SPECIFIC SUBSTRATE FOR MAO‐A IN THE RAT: IMPLICATIONS FOR THE INDOLEAMINE DEPENDENT BEHAVIOURAL SYNDROMEJournal of Neurochemistry, 1975