The screening of chinese crude drugs for Ca2+ antagonist activity: Identification of active principles from the aerial part of Pogostemon cablin and the fruits of Prunus mume.
- 1 January 1989
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 37 (2), 345-348
- https://doi.org/10.1248/cpb.37.345
Abstract
Hot aqueous extracts of 134 Chinese crude drugs were subjected to screening for inhibitory activity on K+ contracture of guinea pig taenia coli, and significant activity was observed in 17 crude drugs. Chemical investigations of two crude drugs, Kakko and Ubai, which originate from Pogostemon cablin and Prunus mume, respectively, were undertaken, and patchouli alcohol (I) and 5-(hydroxymethyl)-2-furaldehyde (II) were identified as their active principles, respectively.This publication has 6 references indexed in Scilit:
- Screening Test for Calcium Antagonists in Natural ProductsYAKUGAKU ZASSHI, 1986
- The Ca2+ antagonist activity of lignans.CHEMICAL & PHARMACEUTICAL BULLETIN, 1986
- Screening Test for Calcium Antagonists in Natural Products and the Active Principles of Cnidii monnieriYAKUGAKU ZASSHI, 1985
- Inhibition of prostaglandin biosynthesis by the constituents of medicinal plants.CHEMICAL & PHARMACEUTICAL BULLETIN, 1983
- Inhibition of cyclic AMP phosphodiesterase by lignans.CHEMICAL & PHARMACEUTICAL BULLETIN, 1981
- Antihypertensive effect of cardiovascular Ca2+-antagonist in hypertensive patients in the absence and presence of beta-adrenergic blockadeAmerican Heart Journal, 1978