Detection of monoclonal plasma cells in the peripheral blood stem cell harvests of patients with multiple myeloma
- 1 March 1995
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 89 (3), 640-642
- https://doi.org/10.1111/j.1365-2141.1995.tb08378.x
Abstract
We evaluated the harvest product from 47 patients undergoing peripheral blood (BP) stem cell collections for monoclonal plasma cells (PC) using a sensitive immunofluorescence technique. 60% (28/47) had docu mented tumour cells in the apheresis product. The 32 patients in plateau had a mean of 1.62 x 106 PC/1 v 74.64 x 106 in 15 relapsed patients (P < 0.01). 32% (6/19) of patients without any tumour cells in the initial sample had them detected on a subsequent apheresis sample. In four cases (all treated with GM‐CSF) small numbers of tumour cells were detected initially but became undetectable on a subsequent sample.Keywords
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