Gas-liquid chromatographic separation of the optical isomers of some “ephedrines” and “pseudoephedrines”
- 1 May 1973
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 25 (5), 382-386
- https://doi.org/10.1111/j.2042-7158.1973.tb10032.x
Abstract
Gas-liquid chromatographic separation of the optical isomers of norephedrine, norpseudoephedrine, ephedrine, pseudoephedrine, N-ethylnorephedrine and N-ethylnorpseudoephedrine by means of their N-trifiuoroacetyl-L-prolyl derivatives has been investigated. A quantitative determination of the enantiomeric percentages was possible for the primary amines, and for all secondary amines except pseudoephedrine. The method is suitable for metabolic studies.Keywords
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