Population Dynamics of Immune Responses to Persistent Viruses
- 5 April 1996
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 272 (5258), 74-79
- https://doi.org/10.1126/science.272.5258.74
Abstract
Mathematical models, which are based on a firm understanding of biological interactions, can provide nonintuitive insights into the dynamics of host responses to infectious agents and can suggest new avenues for experimentation. Here, a simple mathematical approach is developed to explore the relation between antiviral immune responses, virus load, and virus diversity. The model results are compared to data on cytotoxic T cell responses and viral diversity in infections with the human T cell leukemia virus (HTLV-1) and the human immunodeficiency virus (HIV-1).Keywords
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