Children of Mothers with Down's Syndrome

Abstract

IN only two of the syndromes associated with chromosome abnormalities described in man has fertility been reported. These patients are women with the XXX syndrome or with mongolism. Both events are of considerable interest, for the phenomenon of secondary nondisjunction has been exploited in genetic investigations ever since Bridges¹ coined the term in 1916. No detailed account of the children borne to XXX mothers has yet been published. This paper gives the clinical and cytogenetic data on the Lapeer family, consisting of a mother and child, both with mongolism, originally recorded by Rehn and Thomas,² more recently by Stiles and . . .