Female sexual partners of injection drug users are at risk for AIDS because of their association with street drug cultures and all their concomitant risks, including their own non-injecting drug use. This study examines a model of the social determinants of HTV-associated sexual risk behaviors. Multiple Linear regression analysis was used to analyze the data for 207 female sexual partners who had never injected drugs. The findings show that crack cocaine use is the strongest conhbutor to the model, which explains fourteen percent of the variance of sexual risk behavior. The fmdings suggest that the risks associated with sexual practices are much greater for crack cocaine users than among non users of crack.