Inhibition of Amphotericin B (Fungizone) Toxicity to Cells by Egg Lecithin-Glycocholic Acid Mixed Micelles
- 1 December 1990
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 34 (12), 2415-2416
- https://doi.org/10.1128/aac.34.12.2415
Abstract
Mixed micelles prepared from egg lecithin and the sodium salt of glycocholic acid markedly inhibited amphotericin B toxicity to mammalian cells without significantly affecting the antifungal effects of the drug.This publication has 10 references indexed in Scilit:
- Amphotericin B: delivery systemsAntimicrobial Agents and Chemotherapy, 1990
- Amphotericin B: current understanding of mechanisms of actionAntimicrobial Agents and Chemotherapy, 1990
- Affinity of amphotericin B for phosphatidylcholine vesicles as a determinant of the in vitro cellular toxicity of liposomal preparationsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1990
- Liposomes prepared dynamically by interactions between bile salt and phospholipid moleculesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1989
- Comparative Bioavailability Studies with a New Mixed-micelles Solution of Diazepam Utilizing Radioreceptor Assay, Psychometry and EEG Brain MappingInternational Clinical Psychopharmacology, 1988
- Unusual lipid structures selectively reduce the toxicity of amphotericin B.Proceedings of the National Academy of Sciences, 1988
- Effects of the detergent sucrose monolaurate on binding of amphotericin B to sterols and its toxicity for cellsBiochemical and Biophysical Research Communications, 1988
- Effect of lipid composition and liposome size on toxicity and in vitro fungicidal activity of liposome-intercalated amphotericin BAntimicrobial Agents and Chemotherapy, 1987
- Liposomal amphotericin B is toxic to fungal cells but not to mammalian cellsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1984
- Preclinical safety evaluation of intravenously administered mixed micelles.1984