Asymmetric Synthesis of Substituted Isoxazolidinone from α,β-Unsaturated Esters and Hydroxylamines by means of Double Stereodifferentiation

Abstract

Asymmetric synthesis of isoxazolidinones (1) has been developed by Michael addition and ensuing transesterification processes employing chiral hydroxylamines and α,β-unsaturated esters carrying chiral α-hydroxycarboxylic acid ester unit as an alkoxide moiety.