Morphologic and Hemodynamic Changes in the Smaller Blood Vessels in Diabetes Mellitus

Abstract

The importance of vascular degeneration in diabetes mellitus cannot be overemphasized. White and Waskow¹ noted that of 220 juvenile diabetic patients who survived for twenty years 92 per cent gave manifestations of vascular disease, and Keiding et al.² found that among 451 patients with onset of diabetes under the age of thirty years and with a duration of the disease of more than ten years, 49 per cent showed retinopathy, 22 per cent gave definite evidence of diabetic nephropathy, and 47 per cent had marked calcification in larger arteries.Recent studies indicate that the initial degenerative changes in the vascular . . .