UNILATERAL PROVOKED BRONCHIAL ASTHMA IN MAN*
Open Access
- 1 June 1962
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 41 (6), 1236-1241
- https://doi.org/10.1172/jci104585
Abstract
One-sided "asthma" was provoked in two asthmatic subjects with a solution of horse epidermal epithelium inhaled as aerosol into one lung during bronchospirometry. The presence of asthma was demonstrated by a reduction of ventilation and oxygen uptake and a prolonged nitrogen elimination time during oxygen breathing. The uneveness of distribution of inspired gas did not increase significantly, but the ventilatory efficiency decreased, probably as a result of an increased dead space/tidal volume ratio in the provoked lung. No signs of asthma were noted in the unprovoked lung. Epinephrine abolished the asthmatic reaction within 15 seconds, suggesting that bronchospasm was the main causative factor for this kind of asthma. No evidence of a change in "static" compliance during asthma was found. The effect of the unavoidable anesthetic agents is discussed.Keywords
This publication has 3 references indexed in Scilit:
- Respiratory Gases in the Regulation of the Pulmonary CirculationPhysiological Reviews, 1961
- A New Index of the Intrapulmonary Mixture of Inspired AirThorax, 1952
- LUNG FUNCTION STUDIES. VIII. ANALYSIS OF ALVEOLAR VENTILATION BY PULMONARY N2 CLEARANCE CURVES 12JCI Insight, 1952