Infantile Cortical Hyperostoses

Abstract

CAFFEY and Silverman,¹ in July, 1945, published the following description of a new syndrome entitled "infantile cortical hyperostoses":The principal features of the disorder include: onset in the early part of the first year; tender swellings in one or more of these sites — face and jaws, scapular regions and extremities; and multiple scattered hyperostoses demonstrated roentgenographically in bones adjacent to the tender swellings and also in several other bones whose overlying soft tissues appear to be normal, clinically and roentgenographically.... Biopsies of the affected bones in 3 cases showed only hyperplasia of the lamellar cortical bone.Fever was noted . . .