Hypothesis: RNA polymerase: Structural determinat of the chromatin loop and the chromosome
- 1 June 1994
- Vol. 16 (6), 425-430
- https://doi.org/10.1002/bies.950160611
Abstract
Current models for RNA synthesis involve an RNA polymerase that tracks along a static template. However, research on chromatin loops suggests that the template slides past a stationary polymerase; individual polymerases tie the chromatin fibre into loops and clusters of polymerases determine the basic structure of the interphase and metaphase chromosome. RNA polymerase is then both a player and a manager of the chromosome loop.Keywords
This publication has 47 references indexed in Scilit:
- Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleusThe Journal of cell biology, 1993
- GENERAL INITIATION FACTORS FOR RNA POLYMERASE IIAnnual Review of Biochemistry, 1993
- Evidence for channeled diffusion of pre-mRNAs during nuclear RNA transport in metazoans.The Journal of cell biology, 1993
- Core filaments of the nuclear matrix.The Journal of cell biology, 1990
- S Phase of the Cell CycleScience, 1989
- The nucleoskeleton and the topology of transcriptionEuropean Journal of Biochemistry, 1989
- Inhibition of nucleolar reformation after microinjection of antibodies to RNA polymerase I into mitotic cells.The Journal of cell biology, 1987
- Packing of a specific gene into higher order structures following repression of RNA synthesis.The Journal of cell biology, 1984
- RNA is synthesized at the nuclear cageNature, 1981
- On the structure of the folded chromosome of Escherichia coliJournal of Molecular Biology, 1972