Growth Promoting and Inhibitory Activities Of 3T3 and Other Cell Lines for Thiol-dependent Lymphoma Cells in Vitro

Abstract

The growth of thiol-dependent cells of mouse lymphoma L1210(V) is supported by 3T3 and L cell fibroblasts as well as macrophages in vitro. The supporting cells do not permanently condition the medium, but diffusion chamber studies show that growth promotion is mediated humorally. At high cell density inhibition of lymphoma cell growth can be observed in the supernatant from 1 of the 3T3 sublines examined, which appears to be due to a nondialyzable inhibitor whose effect is unrelated to thiol dependency.