Control of HIV despite the Discontinuation of Antiretroviral Therapy

Abstract

Eradication of the human immunodeficiency virus (HIV) is a difficult goal to achieve, because a reservoir of replication-competent HIV is established in resting CD4 T lymphocytes soon after infection and persists after years of highly active antiretroviral treatment.¹ A more realistic alternative to lifelong cumbersome, toxic, and expensive treatments is to control HIV, as occurs in patients with long-term nonprogression of the disease.