T-Cell Immunity to Malaria in the B-Cell Deficient Mouse *
- 1 January 1979
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 28 (1), 1-3
- https://doi.org/10.4269/ajtmh.1979.28.1
Abstract
Some B-cell deficient mice drug-rescued with clindamycin HCl from otherwise lethal infections with Plasmodium yoelii resisted subsequent challenge with the same parasite despite the fact that they lacked detectable antibody to plasmodia. Parasitemias remained patent but at low levels (≤5%) in these mice for prolonged periods of time, suggesting that some T-cell function independent of antibody formation can in part mediate immunity to malaria.This publication has 4 references indexed in Scilit:
- Splenomegaly, enhanced phagocytosis, and anemia are thymus-dependent responses to malariaInfection and Immunity, 1978
- Prevention of recrudescent malaria in nude mice by thymic grafting or by treatment with hyperimmune serumInfection and Immunity, 1977
- Spleen-Derived Mononuclear Cell Chemotactic Factor in Malaria Infections: A Possible Mechanism for Splenic Macrophage AccumulationThe Journal of Immunology, 1977
- IMMUNITY TO PLASMODIUM BERGHEI YOELII IN MICE .1. COURSE OF INFECTION IN T-CELL AND B-CELL DEFICIENT MICE1976