Antibacteroides and β-lactamase inhibitory activities of moxalactam

Abstract

The in-vitro activity of moxalactam against Bacteroides species was investigated and compared to those of other newer cephalosporins. Moxalactam was most active at 2 mg/l inhibiting 74% of the strains tested; whereas, only 20% were inhibited by cefoxitin and none were inhibited by cefotaxime, cefoperazone or ceftizoxime. The stability to β-lactamase hydrolysis of moxalactam and its β-lactamase inhibitory activity were compared to those of newer cephalosporins and penicillanic acid suiphone. Moxalactam and cefoxitin were not hydrolyzed by β-lactamases produced by the Bacteroides tested. On weight basis, moxalactam was a more potent inhibitor than cefoxitin and penicillanic acid sulfone against Bact. fragills β-lactamase. Cefotaxime was not an inhibitor of Bacteroides β.-lactamases.