Reflex control of breathing following inhalation of cigarette smoke in conscious dogs

Abstract

The acute ventilatory response to spontaneously inhaled cigarette smoke (750 ml, 10% concentration) was studied in 92 experiments on 6 awake resting dogs, Upon the 1st or 2nd breath of smoke inhalation an apnea or an augmented breath was elicited consistently in each dog, and a hyperpnea occurred subsequently. Minute ventilation (.ovrhdot.VE) increased from a base line of 3.2 to a peak of 23.9 1/min at 8.3 s (mean values) after the smoke was completely inhaled and returned toward base line in 1-3 min. Cold blocking of both vagi (exteriorized in skin loops) eliminated the initial change in breathing pattern but did not significantly reduce the delayed hyperpnea. Denervation of carotid body chemoreceptors alone abolished 71.5% of the increase in .ovrhdot.VE induced by cigarette smoke. The apnea or augmented breath immediately following smoke inhalation was mediated through vagal afferents; the delayed hyperpnea resulted from the stimulation of carotid body chemoreceptors, prsumably by the absorbed nicotine.