Continuous c-fos expression precedes programmed cell death in vivo
- 13 May 1993
- journal article
- Published by Springer Nature in Nature
- Vol. 363 (6425), 166-169
- https://doi.org/10.1038/363166a0
Abstract
The development of a multicellular organism involves a delicate balance among the processes of proliferation, differentiation and death. Naturally occurring cell death aids tissue remodelling, eliminates supernumerary cell populations and provides structural elements such as hair and skin. In the nervous system, selective cell death contributes to the formation and organization of the spinal cord and sympathetic ganglia, retina and corpus callosum. But cell death also occurs in several neuropathological conditions, such as amyelotrophic lateral sclerosis and Alzheimer's disease. Therefore an elucidation of the mechanisms responsible for cell death is critical for an appreciation of both normal development and neuropathological disorders. Using a fos-lacZ transgenic mouse, we provide evidence showing that the continuous expression of Fos, beginning hours or days before the morphological demise of the cell, appears to be a hallmark of terminal differentiation and a harbinger of death.Keywords
This publication has 20 references indexed in Scilit:
- Medial edge epithelium fate traced by cell lineage analysis during epithelial-mesenchymal transformation in vivoDevelopmental Biology, 1992
- Transient c-fos expression accompanies naturally occurring cell death in the developing interhemispheric cortex of the ratDevelopmental Brain Research, 1992
- Fos-IacZ transgenic mice: Mapping sites of gene induction in the central nervous systemNeuron, 1992
- Glutamate dysfunction and selective motor neuron degeneration inamyotrophic lateral sclerosis: A hypothesisAnnals of Neurology, 1990
- Neurotrophic moleculesAnnals of Neurology, 1989
- Cascade Induction of c-fos, c-myc, and Heat Shock 70K Transcripts during Regression of the Rat Ventral Prostate GlandMolecular Endocrinology, 1988
- Death of the subcallosal glial sling is correlated with formation of the cavum septi pellucidiJournal of Comparative Neurology, 1988
- Role of cell death in the topogenesis of neuronal distributions in the developing cat retinal ganglion cell layerJournal of Comparative Neurology, 1987
- Proto-oncogene c-fos expression in growth regions of fetal bone and mesodermal web tissueNature, 1987
- Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological studyNeuroscience, 1980