The effect of administration of an acetate on detoxication and therapeutic activity of sulphanilamide

Abstract

Administration of Na acetate along with sulphanilamide to mice leads to increased amounts of acetylsulphanilamide being formed and voided in the urine; this increase is coincident with a diminution of the amts. of p-aminophenol and p-hydroxylaminobenzenesulphonamide excreted. The curative value of sulphanilamide for 2 strains of Group A hemolytic streptococci used was not lowered by this treatment but the acute toxic symptoms of the drug were beneficially modified.