GAMMA-GLUTAMYL TRANSPEPTIDASE AND MALIGNANT TRANSFORMATION OF CULTURED LIVER-CELLS

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 39 (1), 269-272
Abstract
The relationship between .gamma.-glutamyl transpeptidase (GGT) and malignant cell transformation was analyzed in maligant and nonmalignant culture epithelial cell lines derived from rat livers and fibroblastic cell types derived from hamsters and mice. GGT activity was prominent (25 to 90% of cells) in 3 of 5 malignant epithelial liver cell lines. None of the 9 fibroblastic or 4 nonmalignant epithelial cell lines exhibited GGT activity. Use of GGT activity allows detection of a significant fraction of the spontaneously or chemically induced maligant cells. In conjunction with other markers, this marker may help in identifying tumorigenic cells in liver epithelial cultures.

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