Cigarette Smoking Increases Gastric Luminal Prostaglandin F2α and Thromboxane B2 in Healthy Smokers

Abstract

Pentagastrin-stimulated gastric luminal prostaglandin E₂ (PGE₂), 6-keto-PGF_1α, PGF_2α and thromboxane B₂ (TxB₂) were measured using a second antibody solid-phase enzyme immunoassay before, during and after cigarette smoking in healthy smokers. Smoking significantly increased PGF_2α and TxB₂ concentration and output; in contrast no significant changes were found for PGE₂ and 6-keto-PGF_1α levels. In addition, cigarette smoking caused a significant reduction in gastric juice volume and acid output but did not alter intragastric acidity. These findings may suggest a possible role of prostanoids in the response of the stomach to cigarette smoking.