THE INHIBITION OF SULPHANILAMIDE ACETYLATION BY AROMATIC AND HETEROCYCLIC CARBOXAMIDES AND CARBOXHYDRAZIDES
- 1 March 1955
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 33 (2), 107-111
- https://doi.org/10.1139/o55-016
Abstract
The acetylation of sulfanilamide by pigeon liver extracts was found to be markedly inhibited by amides of salicylic, 5-bromosalicylic, 5-methylsalicylic, and 6_aminonicotinic acids, and by hydrazides of benzoic, salicylic, 4-aminosalicylic, nicotinic, and isonicotinic acids, as well as by p-aminosalicylic acid. The inhibition of salicylamide and isonicotinyl-hydrazide (isoniazid) was shown to be competitive in nature.Keywords
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- The Determination of Enzyme Dissociation ConstantsJournal of the American Chemical Society, 1934