Epstein–Barr Virus–Associated Lymphoma after Treatment of Macroglobulinemia with Cladribine
- 1 July 1999
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 341 (1), 55
- https://doi.org/10.1056/NEJM199907013410112
Abstract
Purine analogues, including cladribine (2-chlorodeoxyadenosine), are increasingly used in the treatment of Waldenström's macroglobulinemia and other hematologic cancers.1 Cladribine can cause profound immunosuppression, lymphopenia, and increased susceptibility to opportunistic infections.2 We report on a patient with Waldenström's macroglobulinemia in whom an Epstein–Barr virus (EBV)–associated diffuse large-cell lymphoma developed after treatment with cladribine.Keywords
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