Selection of Intrinsic Horizontal Connections in the Visual Cortex by Correlated Neuronal Activity
- 10 January 1992
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 255 (5041), 209-212
- https://doi.org/10.1126/science.1372754
Abstract
In the visual cortex of the brain, long-ranging tangentially oriented axon collaterals interconnect regularly spaced clusters of cells. These connections develop after birth and attain their specificity by pruning. To test whether there is selective stabilization of connections between those cells that exhibit correlated activity, kittens were raised with artificially induced strabismus (eye deviation) to eliminate the correlation between signals from the two eyes. In area 17, cell clusters were driven almost exclusively from either the right or the left eye and tangential intracortical fibers preferentially connected cell groups activated by the same eye. Thus, circuit selection depends on visual experience, and the selection criterion is the correlation of activity.Keywords
This publication has 25 references indexed in Scilit:
- Horizontal Interactions in Cat Striate Cortex: I. Anatomical Substrate and Postnatal DevelopmentEuropean Journal of Neuroscience, 1990
- Ocular Dominance Column Development: Analysis and SimulationScience, 1989
- Oscillatory responses in cat visual cortex exhibit inter-columnar synchronization which reflects global stimulus propertiesNature, 1989
- Topographic organization of the orientation column system in large flat‐mounts of the cat visual cortex: A 2‐deoxyglucose studyJournal of Comparative Neurology, 1987
- The postnatal development of clustered intrinsic connections in area 18 of the visual cortex in kittensDevelopmental Brain Research, 1986
- Regressive events in the postnatal development of association projections in the visual cortexNature, 1985
- Widespread Periodic Intrinsic Connections in the Tree Shrew Visual CortexScience, 1982
- Absence of ocular dominance patches in dark-reared catsNature, 1981
- Effects of visual experience on the maturation of the efferent system to the corpus callosumNature, 1979
- Globality and stereoscopic fusion in binocular visionJournal of Theoretical Biology, 1975