Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test
- 1 January 1985
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 86 (1-2), 170-174
- https://doi.org/10.1007/bf00431704
Abstract
The role of corticotropin-releasing factor (CRF) in mediating the stress response was studied using a behavioral test in which anxiety or conflict influence performance. Rats implanted with intraventricular cannulae were tested in a Geller-Seifter conflict test modified for incremental shock. CRF produced a dose-dependent attenuation of punished and nonpunished responding in the conflict test. Chlordiazepoxide increased punished, but not unpunished, responding and produced a dose-dependent reversal of CRF-induced response suppression. CRF had no effect on tail flick or hot-plate analgesia tests. The results support the hypothesis that CRF produces behavioral effects consistent with “anxiety” or an increased responsiveness to stress.Keywords
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