Macrophage Migration in Experimental Atherosclerosis
- 1 October 1951
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 4 (4), 557-562
- https://doi.org/10.1161/01.cir.4.4.557
Abstract
With the object of testing the importance of macrophage transport of lipid in the production of atheromas, a radioisotope was employed in labeling reticuloendothelial cells. Rabbits were injected with this isotope, and lipemia induced by cholesterol feeding. Subsequently the animals were sacrificed and the distribution of the label determined. High concentrations of the label were found in Kupffer cells, in splenic and marrow macrophages, but no significant increase was demonstrated in aortic atheromas. This finding is interpreted as evidence against the macrophage theory of genesis of atherosclerosis.Keywords
This publication has 2 references indexed in Scilit:
- STUDIES WITH COLLOIDS CONTAINING RADIOISOTOPES OF YTTRIUM, ZIRCONIUM, COLUMBIUM, AND LANTHANUM .2. THE CONTROLLED SELECTIVE LOCALIZATION OF RADIOISOTOPES OF YTTRIUM, ZIRCONIUM, AND COLUMBIUM IN THE BONE MARROW, LIVER, AND SPLEEN1949
- Studies with Colloids Containing Radioisotopes of Yttrium, Zirconium, Columbium, and Lanthanum: 1. The Chemical Principles and Methods Involved in Preparation of Colloids of Yttrium, Zirconium, Columbium, and LanthanumPublished by Office of Scientific and Technical Information (OSTI) ,1948