Self-reactive γδ T cells are eliminated in the thymus
- 1 February 1990
- journal article
- Published by Springer Nature in Nature
- Vol. 343 (6260), 714-719
- https://doi.org/10.1038/343714a0
Abstract
The genes encoding a gamma delta T-cell receptor specific for a major histocompatibility complex class I molecule encoded by the TIa locus have been inserted into the mouse germ line. In mice that do not express the TIa-encoded determinant, transgenic gamma delta T cells are a functional component of the CD4-CD8- 'double-negative' T cells in the thymus and peripheral lymphoid organs. In mice that express the TIa-encoded determinant, there are no transgenic gamma delta T cells in peripheral lymphoid organs, and there are no thymocytes expressing normal levels of the transgenic gamma delta T-cell receptor.Keywords
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