No Deterioration in Glycemic Control in HNF-1α Maturity-Onset Diabetes of the Young Following Transfer From Long-Term Insulin to Sulphonylureas
Open Access
- 1 November 2003
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 26 (11), 3191-3192
- https://doi.org/10.2337/diacare.26.11.3191-a
Abstract
Maturity-onset diabetes of the young (MODY) accounts for ∼1% of diabetes in the U.K. It is characterized by autosomal dominant inheritance of young-onset diabetes that is not insulin dependent. MODY is frequently misdiagnosed as type 1 diabetes and treated immediately with insulin due to its presentation with marked hyperglycemia in slim adolescents/young adults (1–4). With diagnostic molecular genetic testing now well established, it is possible to make a definitive diagnosis of specific genetic subtypes of MODY (5). HNF-1α mutations account for ∼65% of U.K. MODY (MODY 3) cases. Patients with a mutation in HNF-1α are sensitive to the hypoglycemic action of sulfonylureas (6). This suggests that patients with HNF-1α MODY started on insulin from diagnosis could transfer to a sulfonylurea, as described in isolated …This publication has 8 references indexed in Scilit:
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