Enhanced go, no-go single-lever alternation of mice with septal lesions.

Abstract

Trained 11 normal male HS mice and 9 male HS mice with septal lesions in a go, no-go discrete-trial alternation task with a single retractable lever presented for 9 sec., and withdrawn for 10 sec. Responses on odd-numbered trials resulted in lever retraction and food reinforcement, whereas responses on even-numbered trials resulted in neither food nor retraction of the lever. Lesioned Ss learned the task faster than normals, responding on more reinforced trials and fewer nonreinforced trials. Results are incompatible with the hypothesis that the septum is involved in response inhibition. It is suggested that the septal lesions produced an enhanced cue value for food reward. (PsycINFO Database Record (c) 2006 APA, all rights reserved)