The Aging of Solid Dispersion of Glybornuride in Polethylenglycol 6000

Abstract

Glybornuride is an oral hypoglucaemiant whose solubility in water is considerably increased by solid dispersion in P.E.G. 6000. The present article reports the effect of storage at 25 2 C on such dispersion. After 1 year slight alterations in DSC thermograms and X-Ray diffraction spectra are apparent and in studies of dissolution kinetics there is a significant reduction in the percentage of glybornuride dissolved after 6 and 12 months, but glucaemia levels in rabbits recorded after 6, 9 and 12 months do not differ significantly from those obtained with the freshly prepared dispersion