INVESTIGATIONS ON HISTAMINE IN RHEUMATIC DISEASES

  • 1 January 1982
    • journal article
    • research article
    • Vol. 41 (1), 19-22
Abstract
Histamine, the decarboxylation product of histidine, was determined in serum, leukocytes, synovial fluid and synovial tissue of rheumatic diseases. Histamine level was variable in most of the biological samples. In serum of patients with rheumatoid arthritis histamine was more frequent (50%) than in controls (10%). Leukocyte preparations containing basophil cells did not differ in their histamine concentration. Synovial fluid of rheumatoid arthritis patients showed histamine levels in the range of 1.0-23.4 ng/ml. The results were discussed by means of the pertinent literature.