Genomic Location and Lack of Phosphorylation of the HSV Immediate-Early Polypeptide IE 12
- 1 September 1982
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 62 (1), 17-27
- https://doi.org/10.1099/0022-1317-62-1-17
Abstract
Herpes simplex virus type 1 (HSV-1) induces an immediate-early (IE) polypeptide IE 12. An equivalent polypeptide coded by HSV-2 which migrated slightly more slowly on sodium dodecyl sulfate polyacrylamide gels was identified and designated IE 12.3. Analysis of the serotype of the IE polypeptide induced by 5 HSV-1/HSV-2 intertypic recombinants when correlated with their genome structures showed that IE 12/IE 12.3 mapped in the region spanning the short terminal repeat/short unique region junction. Unlike 4 other IE polypeptides induced by HSV-1 (IEs 175, 110, 68 and 63), IE 12 was not detectably phosphorylated.This publication has 3 references indexed in Scilit:
- Separation and characterization of herpes simplex virus type 1 immediate-early mRNA'sJournal of Virology, 1979
- A RAPID TECHNIQUE FOR DISTINGUISHING HERPES-SIMPLEX VIRUS TYPE 1 FROM TYPE 2 BY RESTRICTION-ENZYME TECHNOLOGYThe Lancet, 1979
- Regulation of herpesvirus macromolecular synthesis V. Properties of α polypeptides made in HSV-1 and HSV-2 infected cellsVirology, 1977