The Spermicidal Powers of Chemical Contraceptives. IV. More Pure Substances

Abstract

1. In the list showing all substances yet tested in the order of their spermicidal powers, the first four substances are all quinones. 2. In the dihydroxybenzenes and their derivatives, the para-position of the two hydroxyl groups confers high spermicidal powers. 3. In the trihydroxybenzenes and their derivatives, the para-position of two of the three hydroxyl groups confers high spermicidal powers. 4. The introduction of a methyl group into quinones and into the di- and trihydroxybenzenes in certain positions increases the spermicidal power. 5. In the hydroxybenzaldehydes and their derivatives, the ortho-position of the hydroxyl and aldehyde groups confers high spermicidal powers. 6. Among the substances so far tested which may be found to be of practical use are orbhovanillin and methoxytoluquinone. These are highly spermicidal, sufficiently soluble and stable in solution. It remains to be seen whether they are harmless to the vagina.