Effect of Excluding Pancreatic Juice from Duodenum on Secretory Response of Pancreas to a Meal

Abstract

When canine pancreatic juice secreted in response to a meal was permanently removed, total volume of juice secreted was significantly greater than when the juice was replaced in the duodenum. A similar reduction in volume of postprandial pancreatic secretion occurred when 0.1 [image] NaHCO3 was instilled into the duodenum in place of pancreatic juice. No similar reduction in secretion occurred when equivalent volumes of isotonic saline soln. were substituted for pancreatic juice.